Arthur Grider

Education

Research

My research focuses on the impact of zinc on changes in micro-RNAs, a potential innovative biomarker for zinc status, to ensure adequate intake associated with optimal health. I am also interested in cellular and tissue zinc metabolism, and the role zinc plays in altering protein levels in tissue samples. 

Teaching

FDNS 3100 Macronutrients and Energy Balance; FDNS 4100/6100 Micronutrient Nutrition; FDNS 4900 Seminar in Foods and Nutrition; FDNS 6400 Advanced Macronutrients

Prior Professional Positions

Awards

Editorial Appointments

Outreach

2002-03 – Chair-Elect, American Society of Nutritional Sciences Vitamin/Mineral Research Interest Section (until June 1, 2003)

2003-04 – Chairman, American Society of Nutritional Sciences Vitamin/Mineral Research Interest Section (June 1, 2003 to May 30, 2004)

2006 – Advisory Panel for the National Science Foundation Major Research Instrumentation Grant Review Panel.

2006 – USDA Bioactive Food Components Grant Review Panel.

2007 – Advisory Panel for the National Science Foundation Major Research Instrumentation Grant Review Panel.

2007 – USDA National Research Initiative Bioactive Food Components for Optimal Health Ad Hoc Reviewer.

2007-16  – Consultant for the Quality Education for Minorities Network Proposal Development Workshop for the NSF Major Research Instrumentation Program.
2008 – National Science Foundation Major Research Instrumentation Grant Review Panel Ad Hoc Reviewer.
2010 – Consultant for the Quality Education for Minorities Network Integration of Mathematics into Lower Division Science Courses Workshop.
2011 – Consultant for the Quality Education for Minorities Network Faculty Early Career Development (CAREER) Program Workshop.
2011-16 – Consultant for the Quality Education for Minorities Network Professional Development and Mentoring Program.

2012-13 – Chair-Elect, American Society of Nutritional Sciences Vitamin/Mineral Research Interest Section (until June 1, 2013).

2012 – Guest Editor for Nutrients Special Issue (vol. 4), “Zinc in Health and Disease.”

2013 – Chair, Zinc and Selenium Minisymposium. April 22nd, 2013. Experimental Biology 2013, Boston, MA.

2013-14 – Chair, American Society of Nutritional Sciences Vitamin/Mineral Research Interest Section (until June 1, 2014).

2013-present – American Society of Nutritional Sciences Vitamin/Mineral Research Interest Section reviewer for mini-symposia abstracts for the annual Experimental Biology meetings.

2013 – Oct. 25-26; Consultant for the Quality Education for Minorities Network Proposal Development Workshop for the NSF Major Research Instrumentation Program.

2013-present – Judge for the American Society for Nutrition Vitamin and Mineral Research Interest Section poster competition held at the Experimental Biology annual meeting.

2015-present – Member of the Austin Journal of Nutrition and Metabolism Editorial Board.

2015-present – Member of the SM Food and Nutritional Disorders Editorial Board.

2015 – Manuscript reviewer for the journal, Nutrire.

2015 – Manuscript reviewer for the journal, Biomolecules.

2015-2017 – Manuscript reviewer for the journal, Nutrients.

2016 – Manuscript reviewer for the journal, Molecules.

2016-present – Member of the American Society for Nutrition Scientific and Education Programs Oversight Committee.

2017 – Grant reviewer for the Oklahoma Agricultural Experiment Station Hatch Project, Oklahoma State University, College of Human Sciences, Nutritional Sciences.

2003-15 – Department of Foods and Nutrition representative for the FACS Leadership Retreat

2005-06 – University Council Committee on Facilities.

2005-06 – Family and Consumer Sciences Deans search.

2005-13 – Department of Foods and Nutrition Undergraduate Coordinator

2006 – FDNS Assistant Professor Search Committee.

2006 – FDNS Instructor Search Committee.

2007- 10 – Presidents Faculty Advisory Committee.

2007- 10 – University Council's Faculty Affairs and Statutes & Bylaws Committees.

2013-present – Member of the Department of Foods and Nutrition Curriculum Committee

2014 – Member of the Department of Foods and Nutrition Diversity Committee

2015-present – Chair of the Department of Foods and Nutrition Diversity Committee

2018-20 – Family and Consumer Sciences University Diversity representative

Books

Grider, A. (2004) Proteomics: Tools for nutrition research in the postgenomic era. In, Genomics and Proteomics in Nutrition. C.D. Berdanier and N. Moustaid-Moussa, eds. Marcel Dekker, Inc. New York. pp. 375-394.

Grider, A. (2006) Chapter 37 Zinc, copper, and manganese. In, Biochemical and Physiological Aspects of Human Nutrition. 2nd edition. M.H. Stipanuk, ed. W.B. Saunders Co., Philadelphia, PA. pp. 1043-1067.

Grider, A. (2012) Chapter 37 Zinc, copper, and manganese. In, Biochemical and Physiological Aspects of Human Nutrition. 3rd edition.  M.H. Stipanuk, M.A. Caudill, eds. W.B. Saunders Co., Philadelphia, PA.

Grider, A. (2018) Chapter 34 Zinc, copper, and manganese. In, Biochemical and Physiological Aspects of Human Nutrition. 4th edition.  M.H. Stipanuk, M.A. Caudill, eds. W.B. Saunders Co., Philadelphia, PA.

Current Classes

FDNS 3010 Special Problems in Foods and Nutrition; FDNS 4100/6100 Micronutrient Nutrition; FDNS 4900 Seminar in Foods and Nutrition; GRSC7770 Graduate Seminar; FDNS 6400 Advanced Macronutrients

Current Research

My current research involves the use of bioinformatic and transcriptomic analyses to determine the effects of zinc on the regulation of small, non-coding RNA transcription. i am particularly interested in determining the mechanisms for controlling zinc-dependent osteogenesis by zinc through its interactions with the metal transcription factor-1/metal regulatory element complex and osteogenic signaling pathways.  

Journal Articles

Grider, A, Young, EM. (1996) The acrodermatitis enteropathica mutation transiently affects zinc metabolism in human fibroblasts. Journal of Nutrition 126:219-224.

Grider, A, Vazquez, F. (1996) Nystatin affects zinc uptake in human fibroblasts. Biological Trace Element Research 54:97-105.

Chang, CY, Muga, SJ, Grider, A. (1998) Zinc uptake into fibroblasts in inhibited by probenecid. Biochimica et Biophysica Acta 1368:1-6.

Grider, A, Lin, YF, Muga, SJ. (1998) Differences in the cellular zinc content and 5’nucleotidase activity of normal and acrodermatitis enteropathica (AE) fibroblasts. Biological Trace Element Research 61:1-8.

Grider, A, Mouat, MF. (1998) The acrodermatitis enteropathica mutation affects protein expression in human fibroblasts: analysis by two dimensional gel electrophoresis. Journal of Nutrition 128:1311-1314.

Muga, SJ, Grider, A. (1999) Partial characterization of a human zinc-deficiency syndrome by differential display. Biological Trace Element Research 68:1-12.

Keller, KA, Chu, Y, Grider, A, Coffield, JA. (2000) Supplementation with L-histidine during dietary zinc repletion improves short-term memory in zinc-restricted young adult male rats. Journal of Nutrition 130:1633-1640.

Tchoulova, Y, Grider, A, Mouat, MF, Hausman, GJ. (2000) Priming with magnesium deficient media inhibits preadipocyte differentiation via potential upregulation of tumor necrosis factor alpha. Biological Trace Element Research 73:101-111.

Keller, KA, Grider, A, Coffield, JA.  (2001) Age dependent influence of dietary zinc restriction on short-term memory in male rats.  Physiology and Behavior 72:339-348.

Mouat, MF, Greenspan, P, Byerley, LO, Grider, A. (2003) Zinc uptake into MCF-10A cells is inhibited by cholesterol depletion. Journal of Nutritional Biochemistry 14:74-80.

Chu, Y, Mouat, MF, Coffield, JA, Orlando, R. Grider, A. (2003) The hippocampal expression of P2X6, a purinergic receptor subunit, is affected by dietary zinc deficiency. Biological Trace Element Research 91:77-87.

Chu, Y, Mouat, MF, Harris, RBS, Coffield, JA, Grider, A. (2003) Water maze performance and changes in serum corticosterone levels in zinc-deprived and pair-fed rats. Physiology and Behavior 78:569-578.

Mouat, M.F., Kolli, K., Orlando, R., Hargrove, J.L., Grider, A. (2005) The effects of quercetin on SW480 colon carcinoma cells: a proteomic study. Nutrition Journal. 4:11-17.

Grider, A., Mouat, M.F., Scrimgeour, A.G. (2007) Consumption of a zinc-depleted diet affects soluble protein expression in rat soleus muscle. Journal of Nutritional Biochemistry 18:753-759.

Grider, A., Mouat, M.F., Mauldin, E.A., Casal, M.L. (2007) Analysis of the liver soluble proteome from bull terriers affected with inherited lethal acrodermatitis. Molecular Genetics and Metabolism 92:249-257.

Neal, A.L., Kabengi, N., Grider, A., Bertsch, P.M. (2011) Differing proteomic responses of the soil bacterium Cupriavidus necator to ZnO nanomaterials and aqueous Zn ions. Nanotoxicology DOI:10.3109/17435390.2011.579633.

Phongpa-ngan, P., Grider, A., Mulligan, J.H., Aggrey, S.E., Wicker. L. (2011) Proteomic analysis and differential expression in protein extracted from chicken with varying growth rate and water holding capacity. Journal of Agricultural and Food Chemistry 59:13181-13187.  DOI: 10.1021/jf202622n

Dempsey, C., McCormick, N.H., Kelleher, S.L., Croxford, T.P., Grider, A., Seo, Y.A. (2012) Marginal maternal zinc deficiency in lactating mice redistributes mammary gland zinc pools, reduces secretory capacity and alters milk composition. Journal of Nutrition 142:655-660.

Grider, A., Wickwire, K., Ho, E., Chung, C., King, J. (2013) Dietary zinc depletion and repletion affects plasma proteins: An analysis of the plasma proteome. Biometals 26:133-140.

Zhou, Y., Harrison, D.E., Love-Meyers, K., Chen, Y., Grider, A., Wickwire, K., Burgess, J.R., Stochelski, M.A., Pazdro, R. (2014) Genetic analysis of tissue glutathione concentrations and redox balance. Free Radical Biology and Medicine 71:157-164.

Grider, A., Lewis, R.D., Laing, E.M., Bakre, A.A., Tripp, R.A. (2015) Zinc affects miR-548n, SMAD4, SMAD5 expression in HepG2 hepatocyte and HEp-2 lung cell lines. Biometals 28:959-966.

Berger, P.K., Pollock, N.K., Laing, E.M., Chertin, V., Bernard, P.J., Grider, A., Shapses, S.A., Ding, K.H., Isales, C.M., Lewis, R.D. (2015) Zinc supplementation increases procollagen type 1 amino-terminal propeptide in premenarcheal girls: a randomized controlled trial. Journal of Nutrition 145:2699–704.

Grider, A., Johnson, C.M. (2016) Establishing and maintaining a STEM research agenda. Research Mentoring Guide for STEM Early Career Faculty at HBCUs. pp 59-65.

Johnson, C.M., Grider, A. (2016) A mentee’s guide to establishing, maintaining, and evaluating a    mentee/mentor relationship.  Research Mentoring Guide for STEM Early Career Faculty at HBCUs. pp 37-47.

Lobene, A.J., Kindler, J.M., Jenkins, N.T., Pollock, N.K., Laing, E.M., Grider, A., Lewis, R.D. (2017) Zinc Supplementation does not alter indicators of insulin secretion and sensitivity in black and white female adolescents. Journal of Nutrition 147:1296–300.

Francis, M., Grider, A. (2018) Bioinformatic analysis of the metal response element and zinc-dependent gene regulation via the metal response element-binding transcription factor 1 in Caco-2 cells. Biometals 31:639-646.

Francis, M., Grider, A. (2018) MiRNA-target interactions in osteogenic signaling pathways involving zinc and the metal regulatory element. International Journal of Biochemistry and Cell Biology. In review.