Hea Jin Park

Education

Research

My research focuses on defining the beneficial role of bioactive food compounds and functional foods in human health and on investigating their mechanisms of action in chronic diseases and perinatal development. For more information, see the Bioactive Compounds and Health Laboratory.

Teaching

Human Nutrition and Food, Honors (FDNS2100H)

Cultural Aspects of Foods and Nutrition (FDNS4630/6630)

Nutrition and Disease Processes II (FDNS8550)

Journal Articles

1. M Fagan, CB Welch, KM Scheulin, S Sneed, J Jeon#, ME Golan, SR Cheek, DA Barany, G Oeltzschner, TR Callaway, Q Zhao, HJ Park, JM Lourenco, KJ Duberstein, FD West. Fecal microbial transplantation limits neural injury severity and functional deficits in a pediatric piglet traumatic brain injury model. Frontiers in Neuroscience, in press, 2023
2. J Jeon#, EE Kaiser, ES Waters, X Yang, JM Lourenco, MM Fagan, KM Scheulin, SE Sneed, SK Shin, HA Kinder, A Kumar, SR Platt, J Ahn, KJ Doberstein, MK Rothrock Jr., TR Callaway, J Xie, FD West, HJ Park*. Tanshionone IIA-loaded nanoparticles and neural stem cell combination therapy improves gut homeostasis and recovery in a pig ischemic stroke model.  Scientific Reports, Feb 13;13(1):2520. 2023
3. I Ahmed, W Revees, W Sun, ST Dubrof#, J Zukaitis, FD West, HJ Park, Q Zhao. Nutritional supplement induced modulations in the functional connectivity of a porcine brain. Nutritional Neurosciences, Jan 19; 1-12, 2023
4. EE Kaiser, ES Waters, X Yang, MM Fagan, KM Scheulin, SE Sneed, S Cheek, J Jeon#, S Shin, H Kinder, A Kumar, SR Platt, KJ Duberstein, HJ Park, J Xie, FD West. Tanshinone IIA-loaded nanoparticle and neural stem cell therapy enhances recovery in a pig ischemic stroke model. Stem Cells Translational Medicine. 2022 
5. J Jeon#, JM Lourenco, MM Fagan, C Welch, SE Sneed, ST Dubrof, KJ Duberstein, TR Callaway, FD West, HJ Park*. Changes in Oral Microbial Diversity in a Piglet Model of Traumatic Brain Injury. Brain Sciences. 2022
6. Y Li, J Feng, HJ Park, H Prabhakar, F Kong. Effect of cinnamon on starch hydrolysis of rice pudding: comparing static and dynamic in vitro digestion models. Food Research International, 2022
7. Y Li, HJ Park, CC Akoh, F Kong. Predicting intestinal effective permeability of different transport mechanisms: comparing ex vivo porcine and in vitro dialysis models. Journal of Food Engineering, 2022
8. J Barta#, SJ Kim, HJ Park*. Energy-dense diets lower in protein, antioxidants, and omega-3 fatty acids among US adults with a self-reported head injury with loss of consciousness: A nationawide study, NHANES 2011-2014. Nutrition Research, 2022
9. ES Waters, EE Kaiser, X Yang, MM Fagan, KM Scheulin, J Jeon#, SK Shin¸ HA Kinder, A Kumar, SR Platt, KJ Duberstein, HJ Park, J Xie, FD West. Intracisternal administration of tanshinone IIA-loaded nanoparticles leads to reduced tissue injury and functional deficits in a porcine model of ischemic stroke. IBRO Reports, 5;10: 18-30, 2021
10. J Jeon#, J Lourenco, EE Kaiser, ES Waters, KM Scheulin, X Fang#, HA Kinder, SR Platt, MJ Rothrock Jr, TR Callaway, FD West, HJ Park*. Dynamic changes in the gut microbiome at the acute stage of ischemic stroke in a pig model. Frontiers in Neuroscience, 3;14: 587986, 2020
11. X Fang#, W Sun, J Jeon#, M Azain, H Kinder, J Ahn, HC Chung, Q Zhao, S Rayalam,  HJ Park*. Perinatal docosahexaenoic acid supplementation improves cognition and alters brain functional organization in piglets. Nutrients, 15; 12(7): E2090, 2020
12. EE Kaiser, ES Waters, MM Fagan, KM Scheulin, SR Platt, J Jeon#, X Fang#, HA Kinder, SK Shin, KJ Duberstein, HJ Park, FD West. Characterization of tissue and functional deficits in a clinically translatable pig model of acute ischemic stroke. Brain Research, 1;1736:146778, 2020
13. X Fang#, M Azain, K Crowe-white, JL Mumaw, JA Grimes, C Schimdt, M Barletta, S Rayalam, HJ Park*. Effect of acute ingestion of green tea extract and lemon juice on oxidative stress and lipid profile in pigs fed high-fat diet. Antioxidants (Basel), 23;8(6): 195, 2019
14. X Fang#, J Chung, E Olsen, Snider I, Earls RH, JH Jeon#, HJ Park*, JK Lee. Depletion of Regulator-of-G-protein signaling-10 in mice exaggerates high-fat diet-induced insulin resistance and inflammation, and this effect is mitigated by dietary green tea extract. Nutrition Research, 70: 50-59, 2019
15. G Simchick, A Shen, B Campbell, HJ Park, FD West, Q Zhao. Pig brains have homologous resting state networks to human brains. Brain Connectivity, 9(7): 566-579, 2019
16. AK Knight, HJ Park+,DB Hausman, J Fleming#, V Andersen, G Rosa, M Caudill, O Malysheva, GPA Kauwell, A Sokolow, S Fisher, AK Smith, LB Bailey. Association between one-carbon metabolism indices and DNA methylation status in maternal and cord blood. Scientific Reports, 15 ;8(1):16873, 2018
17. RA Reed, M Barletta, JA Grimes, JL Mumaw, HJ Park, X Fang#, M Azain, S Giguere, and JE Quandt. Accuracy of an oscillometric blood pressure monitor in anesthetized pigs. Laboratory Animals. 52(5):490-496, 2018
18. NM Hohos, AK Smith, HJ Park, DB Hausman, LB Bailey, DC Shade, RB Meagher. CD4+ and CD8+ T cell-specific DNA cytosine methylation differences associated with obesity. Obesity (Silver Spring), 26(8): 1312-1321, 2018
19. Park HJ*, Bailey LB, Shade DC, Hausman DB, Hohos NM, Meagher RB, Kauwell GP, Lewis RD, Smith AK. Distinctions in gene-specific changes in DNA methylation in response to folic acid supplementation between women with normal weight and obesity. Obesity Research and Clinical Practice. 11(6): 665-676, 2017.
20. DC Shade, HJ Park*, DB Hausman, Hohos NM, RB Meagher, GPA Kauwell, V Kilaru, RD Lewis, AK Smith, LB Bailey. DNA Methylation Changes in Whole Blood and CD16+ Neutrophils in Response to Chronic Folic Acid Supplementation in Women of Childbearing Age. International Journal for Vitamin and Nutrition Research. 87 (5-6):271-278, 2017
21. AK Knight, JM Craig,… Park HJ,… AK Smith. An epigenetic clock for gestational age at birth based on blood methylation data. Genome Biology. 2016 Oct 7;17(1):206. doi: 10.1186/s13059-016-1068-z. PubMed PMID: 27717399; PubMed Central PMCID: PMC5054584.
22. JD Gordon#, DB Hausman, LB Bailey, RD Lewis, EM Laing, HJ Park*. Impact of gluten-containing foods on folate intake of women of childbearing age. The Digest, Research Dietetics Practice Group's newsletter, 51(1): 2-7, 2016
23. MY Chung, E Mah, C Masterjohn, SK Noh, HJ Park, RM Clark, YK Park, JY Lee, RS Bruno. Green Tea Lowers Hepatic COX-2 and prostaglandin E2 in rats with dietary fat-induced nonalcoholic steatohepatitis. Journal of Medicinal Food, 18(6) : 648-55, 2015
24. E Mah, SK Noh, KD Ballard, HJ Park, JS Volek, RS Bruno. Supplementation of a γ-tocopherol-rich mixture of tocopherols in healthy men protects against vascular endothelial dysfunction induced by postprandial hyperglycemia. Journal of Nutritional Biochemistry 24(1):196-203, 2013
25. HJ Park, JY Lee, MY Chung, YK Park, AM Bower, SI Koo, C Giardina, RS Bruno. Green tea extract suppresses NFκB activation and inflammatory responses in diet-induced obese rats with nonalcoholic steatohepatitis. Journal of Nutrition. 142(1):57-63. 2012
26. MY Chung, HJ Park, JE Manautou, SI Koo, RS Bruno. Green tea extract protects against nonalcoholic steatohepatitis in ob/ob mice by decreasing oxidative and nitrative stress responses induced by pro-inflammatory enzymes. Journal of Nutritional Biochemistry. 23(4):361-7. 2012
27. JM Bustamante, HJ Park, RL Tarleton. Report of the 2nd Chagas Drug Discovery Consortium meeting, held on 3 November 2010; Atlanta GA, USA. Expert Opinion on Drug Discovery. 6(9):965-73. 2011
28. Y Yang, JM Seo, A Nguyen, TX Pham, HJ Park, Y Park, B Kim, RS Bruno, J Lee. Astaxanthin-rich extract from the green alga Haematococcus pluvialis lowers plasma lipid concentrations and enhances antioxidant defense in apolipoprotein E knockout mice. Journal of Nutrition. 141(9):1611-7. 2011
29. DC Montrose, NA Horelik, JP Madigan, GD Stoner, L Wang, RS Bruno, HJ Park, C Giardina, DW Rosenberg. Anti-inflammatory effects of freeze-dried black raspberry powder in ulcerative colitis. Carcinogenesis, 32(3):343-50. 2011
30. HJ Park, DD DiNatale, M-Y Chung, Y-K Park, J-Y Lee, SI Koo, M O’Connor, JE Manautou, RS Bruno. Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhances hepatic antioxidant defenses in ob/ob mice. Journal of Nutritional Biochemistry, 22(4):393-400, 2011
31. MY Chung, SF Yeung, HJ Park, JS Volek, RS Bruno. Dietary α- and γ-tocopherol supplementation attenuates lipopolysaccharide-induced oxidative stress and inflammatory-related responses in an obese mouse model of nonalcoholic steatohepatitis. Journal of Nutritional Biochemistry, 21(12): 1200-6, 2010
32. HJ Park, E Mah, RS Bruno. Validation of high-performance liquid chromatography-boron-doped diamond detection for assessing hepatic glutathione redox status. Analytical Biochemistry, 15: 407(2): 151-9, 2010
33. HJ Park, RS Bruno. Hepatoprotective activities of green tea in nonalcoholic fatty liver disease. AGRO FOOD INDUSTRY HI-TECH, 21(n1): 37-40, 2010
34. HJ Park, SR Davis, H Liang, D Rosenberg, RS Bruno. Chlorogenic acid differentially alters hepatic and small intestinal thiol redox status without protecting against Azoxymethane-induced colon carcinogenesis in mice. Nutrition and Cancer, 62(3): 362-70, 2010