Robert Pazdro

Education

Research

My research group is working to improve the human experience by eliminating the burdens of chronic medical conditions, such as liver disease and heart failure. We focus on two risk factors long considered to be fixed and unmodifiable – genetics and age – and how they impact disease development, with emphases on metabolism, hormone activity, and organ structure and function. Through our work, we are contributing to the future of personalized medicine and discovering the next generation of exciting therapeutic targets to treat chronic diseases, restore health, and vastly improve lives. 

For more information, see the Complex Diseases Laboratory.

Teaching

FDNS 8560 Proposal Writing (Spring Semester); FDNS 4570/6570 Inherited Metabolic Disorders (Spring Semester); FDNS 2400 Intro to Nutrition Science (Fall Semester)

Current Research

Our current research projects include:

R01 GM121551 NIH/NIGMS Defining the Genetic Architecture of the Glutathione Redox System; Role: Principal Investigator.

Journal Articles

Select Publications:

Gould RL and Pazdro R. Impact of supplementary amino acids, micronutrients, and overall diet on glutathione homeostasis (Review). Nutrients 2019; 11(5): 1056.

Gould RL, Zhou Y, Yakaitis CL, Love K, Reeves J, Kong W, Coe E, Xiao Y, and Pazdro R. Heritability of the aged glutathione phenotype is dependent on tissue of origin. Mammalian Genome 2018; 29(9-10): 619-631.

Bumgardner SA, Zhou Y, Jiang Z, Coe EJ, Yakaitis CL, Xiao Y, and Pazdro R. Genetic influence on splenic natural killer cell frequencies and maturation among aged mice. Experimental Gerontology 2018; 104: 9-16.

Norris KM, Okie W, Kim WK, Adhikary R, Yoo S, King S, and Pazdro R. A high-fat diet differentially regulates glutathione phenotypes in the obesity-prone mouse strains DBA/2J, C57BL/6J, and AKR/J. Nutrition Research 2016; 36: 1316-1324.

Norris KM, Okie W, Yakaitis CL, and Pazdro R. The anthocyanin cyanidin-3-O-beta-glucoside modulates murine glutathione homeostasis in a manner dependent on genetic background. Redox Biology 2016; 9:254-263.

Jiang Z, Harrison DE, Parsons ME, McClatchy S, Jacobs L, and Pazdro R. Heritability of in vitro phenotypes exhibited by murine adipose-derived stromal cells. Mammalian Genome 2016; 27(9-10): 460-468.

Zhou Y, Jiang Z, Harris EC, Reeves J, Chen X, and Pazdro R. Circulating concentrations of growth differentiation factor 11 are heritable and correlate with life span. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2016; 71:1560-1563.

Zhou Y, Harrison DE, Love-Myers K, Chen Y, Grider A, Wickwire K, Burgess JR, Stochelski MA, and Pazdro R. Genetic analysis of tissue glutathione concentrations and redox balance. Free Radical Biology & Medicine 2014; 71: 157-164.